Welcome to the Zhang Group

We develop machine learning and artificial intelligence–driven multiscale simulation technologies to explore how molecular interactions give rise to biological organization.

By combining theoretical chemistry, statistical physics, and data-driven modeling, we create computational tools that bridge atomic-level chemistry and genome-scale biology. These tools enable large-scale simulations of chromatin organization, helping to uncover the sequence–structure–function relationships encoded in the genome and potentially guide genome engineering and inspire new therapeutic strategies for diseases such as Alzheimer’s.

We are grateful for funding from National Institute of Health, National Science Foundation, Research Corporation, and from Gordon and Betty Moore Foundation.